Tomb of Annihilation is a perilous jungle expedition and deathtrap dungeon crawl set in the exotic land of Chult, a lush and untamed peninsula filled with ancient ruins, deadly beasts, and primeval magic. This high-stakes campaign thrusts players into a race against time to end a mysterious death curse plaguing the world—one that prevents resurrection and slowly drains the life from those previously restored to life. From the bustling port city of Nyanzaru to the deepest reaches of the undead-infested jungle, adventurers must brave treacherous terrain, unravel ancient mysteries, and survive relentless threats.

​

The adventure emphasizes survival and exploration, with players charting their own course through an open-world wilderness teeming with dangers, from dinosaur stampedes and hidden cults to lost cities and cursed tombs. At its heart lies the forbidding Tomb of the Nine Gods, a lethal megadungeon riddled with fiendish traps, cruel puzzles, and monstrous guardians—all part of a twisted game designed by the powerful lich Acererak. As players delve deeper, they uncover grim lore, ancient rivalries, and the true scope of Acererak’s sinister design.